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The subsiding of the COVID-19 pandemic and the various effects it could have on the health of infected patients in the long term have prompted researchers to conduct studies in this field. One of the most notable issues is the finding of a relation ship between SARS-CoV-2 infection and the development of cancer in human organs.

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Myelodysplastic syndrome (MDS) is defined by inadequate hematopoiesis and a risk of progression to acute myeloid leukemia (AML). This case report describes a 59-year-old individual with MDS who has a complicated karyotype that in cludes chromosomal 1q triplication (q21q32) and grade 2 myelofibrosis (MF-2). The patient had severe cytopenias, recur ring infections, and inflammatory lesions suggestive with pyoderma gangrenosum

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Pulmonary s is a multifactorial chronic progressive disease, caused by numerous biotic and abiotic agents, including SARS-CoV-2 infection. Damage of the alveolar epithelial barrier (formed by alveolar epithelial cells type I, consisting of tight and adherens junctions) has been described as a key mechanism of early s and therefore could be crucial for post-acute sequelae of COVID-19 as well. Integrity of adherens junctions is regulated by the intracellular plaque protein p120 catenin and is crucial for epithelial barrier regulation in epithelial-mesenchymal-transition-driven diseases like nesis and cancer progression

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Staphylococcus aureus and Staphylococcus epidermidis are major agents of nosocomial infections and exhibit high levels of antimicrobial resistance. e CRISPR/Cas system functions as a bacterial defense mechanism against mobile genetic elements, such as phages and plasmids, and may be the acquisition of resistance genes. s study aimed to investigate the presence, diversity, and functional implications of the CRISPR/Cas system in complete genomes of S. aureus and S. epidermidis, including its relationship with integrated bacteriophages, anti-CRISPR genes, and antimicrobial resistance genes. A total of 30 complete genomes from each species were analyzed, all retrieved from the NCBI database

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Sudan blue II/cyclodextrin doped zinc oxide nanoparticles are synthesized and characterized by various spectral and micros copic methods. The doping effect of SBII/CD on ZnO nano was investigated by UV-visible, fluorescence, FTIR, DTA, XRD, FE-SEM, and TEM methods. Nanoparticle size was measured by TEM-EDS and X-RD methods. The effect of different po larities of the solvents, α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD), on SBII was studied by various spectral methods. The thermodynamic properties and stability of the inclusion complexes are studied by PM3 methods.

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Solubilisation efficiency of Soluphor® P (2-pyrrolidone) for itraconazole was exploited for developing a self-emulsifying formulation. The objective of this study was to develop and evaluate self-emulsifying drug delivery system (SEDDS) for improving the delivery of a poorly water-soluble antifungal agent, itraconazole (ITZ). Phase diagrams were constructed at different ratios of surfactant/co-surfactant (Km) to determine microemulsion existence region

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Although dietary magnesium intake is common, its low bioavailability contributes to widespread deficiency in modern pop ulations. This study aims to evaluate the absorption and biological activities of four marine magnesium forms (oxide, cit rate, citrate malate, and bisglycinate) for maximizing magnesium biological effectiveness. Absorption of marine organic magnesium compounds was compared to marine magnesium oxide by Caco-2 intestinal permeability assay and their in vivo bioavailability in mice

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e article shows that the Gibbs energy (free energy) is not energy and that work is done due to the heat of the environ ment, not the Gibbs energy. e change in Gibbs energy at constant values of temperature and pressure in most cases was explained by the performance of work due to Gibbs energy. Gibbs energy has the dimension of energy and this forces many to believe that Gibbs energy is energy. However, work is actually performed due to the heat of the environ ment in an amount equal to the change in Gibbs energy. If , then the process can be used for another process. A decrease in at constant values of and leads the system to equilibrium when .

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Diabetic Kidney Disease (DKD) , a prevalent and severe chronic complication of diabetes, is the leading cause of chronic kid ney disease (CKD) and end-stage renal disease (ESRD) worldwide. The pathophysiology of DKD is multifactorial, involving dysregulated glycolipid metabolism, hemodynamic abnormalities, renin-angiotensin system (RAS) overactivation, inflam mation, autophagy impairment, oxidative stress, mitochondrial dysfunction, and genetic/epigenetic dysregulation. Emerg ing evidence highlights inflammation as a central driver of DKD progression

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Liver cirrhosis remains a major health issue globally. Serum magnesium y is common among liver cirrhosis pa tients, but there are very limited large-scale studies on it. Our study aimed to investigate the serum magnesium level of cir rhotic patients and determine the distribution of serum magnesium y in t etiologies among liver cirrhosis patients, in Hangzhou, China.

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Sjogren’s disease is a chronic autoimmune disease with a wide range of symptoms. A patient can first experience symptoms from dry eyes or dry mouth to eventually progressing to more severe symptoms that can affect several organs in the body. Hair loss can be one of the symptoms that physicians might see as less severe but can have a negative impact on a person’s quality of life.

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We report a 44 year old male patient with recurrent attacks of hypoglycemia (RBS 40-50 mg/dL), neuroglycopenic symp toms, and weight loss, prompting evaluation for causes of hyperinsulinemic hypoglycemia.

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The win ratio is an estimate of the treatment effect used in situations where composite endpoints are employed and where the events that make up the composite endpoint can be prioritized. We study the win ratio in the context of oncology trials with the events of progression and death. We then propose two new measures related to the win ratio, called the continuous win ratio and continuous win difference

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Ultrasound is a critical tool in prenatal care, yet various challenges and barriers can affect its effectiveness. This systematic review aims to identify and synthesize these challenges to inform future research and practice.The primary objective of this review is to address the challenges associated with ultrasound use during pregnancy, focusing on both ma ternal and fetal outcomes. The review seeks to highlight areas needing further investigation and improvement in ultrasound practices.

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Advancements in human knowledge across various scientific fields, including medical sciences such as vaccination, lifestyle, health, medical procedures, pharmacology, and up-to-date screening programs, have contributed to an increase in life expectan cy. However, longevity is associated with multiple non-communicable diseases, such as osteoarthritis, cardiovascular diseases, and cognitive impairment that affect the elderly [1]

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With this special issue of JMSN we are pleased to present significant contributions to a fascinating topic in the field of materials nanostructing, which is the anodization of valve metals. By this treatment porous oxides of controlled geometry can be grown on the respective metal surfaces. To date, aluminum (Al) has been used most often, as confirmed in this special issue where nine out of ten contributions deals with its anodization.

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The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.

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Self-organized anodic porous alumina films with hexagonal pore lattice have attracted a considerable attention for biological arrays and confinement of various organic probes dyes in solutions. A molecular structure with axial symmetry in bis-heterocyclic indole chains and conjugate system, such as cyanine fluorophore Cy3 dye, was investigated here with respect to its fluorescence when loaded in the anodic alumina pores.

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Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.

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Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.

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The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.

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Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.

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The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

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The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.

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Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.

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We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.

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The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.

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Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.

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Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.

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In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.

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