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Recent Articles

Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE Inspired by Bryophyllum pinnatum: A Structural Exploration

This study evaluates the potential of Bryophyllum pinnatum ligands as treatments for Alzheimer's disease (AD) and Parkinson's disease (PD) by targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), enzymes linked to these neurodegenerative disorders. Utilizing Schrödinger Suite and Maestro 12.8 for computer-aided drug design, ligands from B. pinnatum and standard drugs were docked into the active sites of AChE and MAO-B. Further analysis included ADMET screening and MM/GBSA calculations, with pharmacophore modeling to align compounds with reference ligands. The study identified 4 and 6 promising compounds as MAO-B and AChE inhibitors, respectively. Pinoresinol was identified as the most promising candidate, exhibiting optimal binding, favorable blood-brain barrier permeability, and pharmacophoric features similar to those of the standard drug. These findings suggest the neuroprotective capabilities of B. pinnatum ligands, recommending further in vivo and in vitro testing to confirm their therapeutic efficacy

Dosing Time-Dependency of the Arthritis-Inhibiting Effect of Tofacitinib in Mice

Rheumatoid arthritis (RA) has a 24-hour rhythm with a characteristic symptom of morning stiness, which causes pain in the joints from late night to early morning. We previously revealed that higher therapeutic eects were obtained in RA patients and RA animal models when the dosing time of anti-rheumatic drugs was chosen according to the 24-hour rhythms of cytokine and in- ammatory reaction. In this study, we evaluated whether dosing with the Janus-associated kinases inhibitor Tofacitinib while accounting for biological rhythms results in higher therapeutic ecacy

Screening of Visual Pathway in Patients Suffering from Guillain Barre by Visual Evoked Potential

Aim: Guillain-Barre syndrome (GBS) is a rare condition in which a person's immune system attacks the peripheral nerve. The visual system can also be affected in GBS patients. The aim of present work is to look for visual pathway, disturbances in these patients using visual evoked potential (VEP). Material and Methods: 10 male patients (20 eyes) diagnosed as GBS in age range of 25 to 56 years were selected for the purpose of present study. Visual evoked potential (VEP) using pattern type of stimulation was tested in total patient group using Mangoni machine. The results obtained was compared with 10 normal sex and age matched population following VEP test.