Journal of Immunology and Infectious Diseases

The major goal of Dr. Lacorazza’s group is to better understand the molecular control of normal and malignant hematopoiesis, including development and differentiation of CD8+ T cells. His group studies genes involved in the balance between quiescence, a non-proliferative state poised to re-enter the cell cycle, and differentiating proliferation in hematopoietic stem cells and naïve/memory CD8+ T cells. Dr. Lacorazza also investigates the role of these genes in the pathobiology and targeted therapy of pediatric acute lymphoblastic leukemias and the chemoresistance of leukemic stem cells.