Editorial Board Member - JIID
Lan Zhou
Assistant ProfessorDepartment of Pathology
Case Western Reserve University
United States
BIOGRAPHY:
Dr. Zhou completed her PhD thesis studying the gap junction protein regulation by Src oncogene. From 1999 to 2001, Dr. Zhou worked as a Research Associate at HHMI under Dr. John Lowe’s supervision to study how fucosyl- glycans modify selectin ligand activity in myeloid cell homeostasis. Since being recruited to Case Western Reserve University, Dr. Zhou has conducted research to try to understand the functional regulation of hematopoietic stem cell (HSC) fate specification and differentiation, myeloid and lymphoid cell homeostasis, and HSC self-renewal and niche development by fucosylated glycans present on Notch and selectin ligands. Dr. Zhou has also been interested in the role of Notch signaling in pancreatic cancer and aberrant glycosylation in colon carcinogenesis and tumor surveillance. Her long term research goals include
1) to understand the mechanism(s) of which Notch as a signaling molecule and an adhesion molecule in HSC niche retention and quiescence maintenance
2) to identify cellular and/or soluble factors that are critical for suppression of hematopoiesisby leukemia cells that are amenable to disruption
3) to develop a deeper understanding of the role of Notch signaling in pancreatic cancer progression
4) to use mouse models to investigate the mechanisms of aberrant glycosylation induced colitis and colon cancer development.
RESEARCH INTERESTS:
Dr. Zhou long term research focus is to understand the normal hematopoietic stem cell (HSC) niche regulation by Notch and associated adhesion processes, how leukemia regulates marrow micro-environment, and the role of aberrant Notch signaling in pancreatic cancer and colon cancer carcinogenesis and immuno-surveillance.
Other Editorial Board Members - JIID
Jana Barlic-Dicen
Department of Cell Biology
University of Oklahoma Health Sciences Center
United States
Subash Sad
Department of Biochemistry, Microbiology and Immunology
University of Ottawa
Canada
Dayanand Bagdure
Pediatric Critical Care
University of Maryland School of Medicine Baltimore
United States
Jeffrey E. Lee
Laboratory Medicine & Pathobiology
University of Toronto
Canada
Hyung C Woo
School of medicine
University of Maryland
United States
Wen-Quan Zou
Departments of Pathology and Neurology
Case Western Reserve University School of Medicine
United States
Mohammad Ayoub Mir
School of Medicine
University of Kansas
United States
Ramesh C. Gupta
School of Agricultural Sciences and Rural Development (SASRD)
Nagaland University
India
Zezhang Tom Wen
School of Medicine
LSU Health Sciences Center School of Dentistry
United States
Hao Shen
Department of Microbiology
United States