1 Candow DG (2011) Sarcopenia: current theories and the potential beneficial effect of creatine application strategies. Biogerontology 12: 273-81.
2Moon A, Heywood L, Rutherford S, Cobbold C (2013) Creatine supplementation: can it improve quality of life in the elderly without associated resistance training? Curr Aging Sci 6: 251-7.
3 Bemben MG, Lamont HS (2005)
4Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism Physiol Rev 80: 1107-213.
5Kley RA, Vorgerd M, Tarnopolsky MA (2007) Creatine for treating muscle disorders. Cochrane Database Syst Rev.
6 Kushmerick MJ (1998) Energy balance in muscle activity: simulations of ATPase coupled to oxidative phosphorylation and to creatine kinase. Comp Biochem Physiol B Biochem Mol Biol 120: 109-23.
7 Saks VA, Ventura-Clapier R, Aliev MK (1996) Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochim Biophys Acta 1274: 81-8.
8 Sweeney HL (1994) The importance of the creatine kinase reaction: the concept of metabolic capacitance. Med Sci Sports Exerc 26: 30-6.
9 Greenhaff PL, Bodin K, Soderlund K, Hultman E (1994) Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 266: E725-30.
10Branch JD (2003) Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab 13: 198-226.
11 Kreider RB (2003) Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem 244: 89-94.
12 Francaux M, Demeure R, Goudemant JF, Poortmans JR (2000) Effect of exogenous creatine supplementation on muscle PCr metabolism. Int J Sports Med 21: 139-45.
13Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA (2000) Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 32: 291-6.
14Wilder N, Deivert RG, Hagerman F, Gilders R (2001) The Effects of Low-Dose Creatine Supplementation Versus Creatine Loading in Collegiate Football Players. J Athl Train 36: 124-9.
15 Willoughby DS, Rosene JM (2003) Effects of oral creatine and resistance training on myogenic regulatory factor expression. Med Sci Sports Exerc 35: 923-9.
16Hespel P, Op't Eijnde B, Van Leemputte M, Urso B, Greenhaff PL, et al. (2001) Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol 536: 625-33.
17 Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, et al. (2006) Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. J Physiol 573: 525-34
18 Hanssen KE, Kvamme NH, Nilsen TS, Rønnestad B, Ambjørnsen IK, et al. (2013) The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scandinavian J Med Sci in Sports 23: 728-39.
19 Kadi F, Schjerling P, Andersen LL, Charifi N, Madsen JL, et al. (2005) The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles. J Physiol 558: 1005-12.
20Gibson MC, Schultz E (1983) Age-related differences in absolute numbers of skeletal muscle satellite cells. Muscle Nerve 6: 574-80.
21Candow DG, Chilibeck PD (2005) Differences in size, strength, and power of upper and lower body muscle groups in young and older men. J Gerontol A Biol Sci Med Sci 60: 148-56.
22Waters DL, Baumgartner RN, Garry PJ, Vellas B (2010) Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update. Clin Interv Aging 5: 259-70.
23 Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG (2005) Creatine monohydrate and resistance training increase bone mineral content and density in older men. J Nutr Health Aging 9: 352-3.
24 Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A (2007) Resistance Exercise Reverses Aging in Human Skeletal Muscle. PLoS ONE 2: e465.
25 Tarnopolsky MA, Safdar A (2008) The potential benefits of creatine and conjugated linoleic acid as adjuncts to resistance training in older adults. Appl Physiol Nutr Metab 33: 213-27.
26 Poortmans JR, Francaux M (2000) Adverse effects of creatine supplementation: fact or fiction? Sports Med 30: 155-70.
27Bemben MG, Witten MS, Carter JM, Eliot KA, Knehans AW(2010) The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging 14: 155-9.
28 Smith SA, Montain SJ, Matott RP, Zientara GP, Jolesz FA (1985) Creatine supplementation and age influence muscle metabolism during exercise. J Appl Physiol 85: 1349-56.
29 Harris RC, Soderlund K, Hultman E (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond) 83: 367-74.
30 Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, et al. (2001) Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One 2: e991.
31 Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, et al. (2008) Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc 40: 1645-52.
32Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG (2001) Creatine supplementation combined with resistance training in older men. Med Sci Sports Exerc 33: 2111-7.
33 Tipton KD, Ferrando AA, Phillips SM, Doyle D, Wolfe RR (1999) Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol 276: E628-34.
34Gualano B, Macedo AR, Alves CR, Roschel H, Benatti FB, et al. (2014) Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Exp Gerontol 53: 7-15.
35Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB (1995) Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332: 556-61.
36Brose A, Parise G, Tarnopolsky MA (2008) Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol Sci Med Sci 58: 11-9.
37Bermon S, Venembre P, Sachet C, Valour S, Dolisi C (1998) Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand 164: 147-55.
38 Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, et al. (2008) Creatine supplementation improves muscular performance in older women. Eur J Appl Physiol 10: 223-31.
39 Gotshalk LA, Volek JS, Staron RS, Denegar CR, Hagerman FC (2002) Creatine supplementation improves muscular performance in older men. Med Sci Sports Exerc 34: 537-43..
40Bautmans I, Njemini R, Predom H, Lemper JC, Mets T (2008) Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-alpha, interleukin-6, and heat shock protein 70. J Am Geriatr Soc 56: 389-96.
41 Sebedio JL, Angioni E, Chardigny JM, Gregoire S, Juaneda P, et al. (2001) The effect of conjugated linoleic acid isomers on fatty acid profiles of liver and adipose tissues and their conversion to isomers of 16:2 and 18:3 conjugated fatty acids in rats. Lipids 36: 575-82.
42 Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL (2002) Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 16: 325-34.
43 Fielding RA (1995) The role of progressive resistance training and nutrition in the preservation of lean body mass in the elderly. J Am Coll Nutr 14: 587-94.
44Rawson ES, Clarkson PM (2000) Acute creatine supplementation in older men. Int J Sports Med 21: 71-5.
45 Rawson ES, Wehnert ML, Clarkson PM (1999) Effects of 30 days of creatine ingestion in older men. European journal of applied physiology and occupational physiology 8: 139-44.
46 Wiroth JB, Bermon S, Andrei S, Dalloz E, Hebuterne X, et al. (2001) Effects of oral creatine supplementation on maximal pedalling performance in older adults. European journal of applied physiology 84: 533-9.
47 Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, et al. (2007) Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women (64 - 86 years). J Nutr Health Aging 11: 459-64.
48 Ryan AS, Ivey FM, Hurlbut DE, Martel GF, Lemmer JT, et al. (2004) Regional bone mineral density after resistive training in young and older men and women. Scand J Med Sci Sports 14: 16-23.
49Frost HM (1996) Perspectives: a proposed general model of the "mechanostat" (suggestions from a new skeletal-biologic paradigm). Anat Rec 244: 139-47.
50Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17: 1726-33.
51 Syrotuik DG, Bell GJ (2004) Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res 18: 610-7.
52Martini FH, Nath JL (2008) Fundamentals of Anatomy and Physiology. 8th ed Pearson.