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Recent Articles

Penicillin-Streptomycin Induces Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes through MAPK signal pathway

Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin on inducing mouse embryonic stem cells(mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. The time- space expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days. Furthermore, action potentials were measured by patch clamp for mESC-derived cardiomyocytes. Embryonic bodies through hanging drop method, were incubated with penicillin-streptomycin (P/S) at different concentrations (1×PBS, 1×, 2×, 5×), and then, the number of cardiomyocytes and expression levels of myocardial marker proteins were detected by flow cytometry, cellular immunofluorescence, and western blotting, respectively. We found that the SSEA-1 of mESC presented green fluorescence, and H.E. staining showed karyoplasmic ratio >>1. Besides, TNNI3, TNNT2, ACTN2 and MYL-2v were clearly visible by cellular immunofluorescence. Furthermore, the ACTN2 positive cells rate of 2× and 5× groups were remarkably higher than that in Cntl (1×PBS) group and 1× group (10 Units/mL penicillin; 10 μg/mL streptomycin), as well as the expressions of GATA4, MYL-2v, TNNI3, ACTN2

The Use of Silver Nanoparticles Prepared by The Green Method to Reduce The Concentration of Nickel in Water

The present work aims to study a convenient and environmentally friendly method for the green synth of silver nanoparticles (AgNPs based on lemon juice extract. The biomolecules contained in lemon extract act as self- reducing and stabilizing agents. The optimal solution for the synthesis of AgNPs was determined by varying silver nitrate concentrations. A surface plasmon resonance system identified the synthesized silver nanoparticles by their color change from colorless to dark brown. Silver nanoparticles synthesized were characterized by Uv-visible (UV-Vis) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and FTIR spectroscopy. As a result of UV-visible spectroscopy, surface plasmon resonance (SPR) can be determine

Erythodermic Psoriasis Succesfully Treated with Guselkumab

Erythrodermic psoriasis (EP) is severe and potentially life-threating variant of psoriasis.1 EP is defined as psoriasis involving more than 80% body surface area (BSA). In recent years the treatment options for EP have expanded; however international guidelines are lacking and the evidence-based treatment choices like conventional therapies and biologics are mainly from small case series or case report.2-3Guselkumab is a fully human monoclonal antibody designed to bind to the p19 subunit of interleukin-23 (IL-23), that inhibits the inflammatory cascade in psoriatic skin. IL-23 plays a central role in T-helper (Th)17 cell stabilization and survival as well as production of IL-17A, a pro-inflammatory cytokine involved in the pathogenesis of psoriasis.