Male Wistar rats were treated daily and intraperitoneally with CdS-Dextrin nanoparticles (100 μg/kg) during 30, 60, and 90 days. The effect of subacute and chronic administration of CdS-Dextrin nanoparticles on CD4/CD8 subpopulations of thymocytes, spleen-derived T cells, and peripheral blood CD4/CD8/CD3 T cells were analyzed by flow cytometer using a Rat T Lymphocyte Cocktail. An indirect ELISA kit analyzed cytokine Th1/Th2 levels. A DNA content and cell cycle analysis was carried out in bone marrow cells by flow cytometry. We also analyzed the presence of CdS-Dextrin nanoparticles in the thymus and spleen.
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Drug Tolerability and Outcomes in Kidney Transplant Recipients Treated with Two Formulations of Mycophenolic Acid
Mycophenolic Acid (MPA) is one of the most widely used immunosuppressive agents in kidney transplantation. This study was designed to compare the safety, tolerability and efficacy of two formulations of mycophenolic acid, Mycophenolate Mofetil (MMF) and Enteric-Coated Mycophenolate Sodium (EC-MPS), in renal transplant recipients.
Mthfr c677t, Homocysteine and Risk of Splanchnic Vein Thrombosis: A Pooled Analysis of Published Epidemiological Studies
This meta-analysis aimed to comprehensively assess the literature examining a possible link between the methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and homocysteine and the risk of splanchnic vein thrombosis (SVT).
Eating related hormones may be strongly involved in the control of food intake under stressful conditions. The development and maintenance of eating disorders such as obesity, binge eating disorder, and bulimia nervosa might be in part explained by the altered release of insulin, ghrelin or leptin in particular in vulnerable subjects such as restrained eaters. The present investigation describes the secretion of these hormones before and after stress in a sample of 44 young women, who were selected according to a high degree of dietary restraint. Hormones were analysed from blood samples which were drawn 30 and 60 minutes after a validated stressor. Ghrelin levels significantly rise after stress induction. Insulin and Leptin both significantly fall after stress. The results are discussed with regard to biological as well as psychological causes and consequences of stress related hormone release in restrained eaters.