Glyoxal (G) and methylglyoxal (MG) have received cautions for their roles in the atmospheric chemistry and formation of secondary organic aerosol. Mostly they come from the photochemical transformation of precursors like isoprene, aromatic compounds, acetylene and acetone etc. Here these two compounds were studied in Wanqingsha, the central sector of Pearl River Delta (PRD), south China, in deep-autumn from 2008-2011.
NIH Funded Articles
- Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites
- Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study
- Wake-up Strokes Are Similar to Known-Onset Morning Strokes in Severity and Outcome
- Endothelial Cells May Have Tissue-Specific Origins
- Objectively Coding Intervention Fidelity During A Phone-Based Obesity Prevention Study
- Predictors of Obstructive Sleep Apnea Risk among Blacks with Metabolic Syndrome
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Hemoglobin SC Disease with COVID-19 Presenting with Multiple Infarcts and Acute Splenic Sequestration Crises
Hb SC disease is a type of hemoglobinopathy that can be viewed as a hybrid of hemoglobin S and C. In this disorder there is co-inheritance of one Hbs gene and one HbC gene resulting in a milder phenotype than sickle cell anemia (SCA). Whereas SCA clinical features have been extensively studied, very few studies have been dedicated specifically to HbSC disease as most cases are reported to be silent or of mild severity. As the pandemic continues to evolve with the novel Sars-CoV-2 virus we have learned it can lead to thrombotic complications which could be fatal if not detected early. Of those requiring admission to the intensive care unit, most carry multiple comorbidities (hypertension, diabetes mellitus etc.) leading to worse clinical outcomes. Here, we present a case of a young adult patient with silent hemoglobin SC disease who tested positive for SARS-CoV-2 leading to multiple infarcts, splenic sequestration and respiratory failure. The concurrence of a hemoglobinopathy and COVID-19 should warrant heightened clinical suspicion for unusual outcomes. Hence, providers must remain vigilant while treating any patient with any hemoglobinopathy in the setting of COVID-19.
The genomic asymmetry in the nonrandom retention and expression of controlling genes for some traits from one parental diploid is obvious in some natural and synthetic allopolyploids, and has the evolutionary implications. Here we review the genomic asymmetry for the morphological performance in three cultivated Brassica allotetraploids and some intergeneric allopolyploids within Brassicaceae species. For the phenotypic biases of Brassica allotetraploids, Brassica oleracea (genomes CC) is dominant over B. nigra (BB) and B. rapa (AA) in B. carinata (CCBB) and B. napus (CCAA), respectively, and B. nigra is dominant over B. rapa in B. juncea (BBAA), showing the C>B>A dominance hierarchy.
During early embryonic development in female mammals, one copy of the X chromosome is randomly inactivated in a process known as X chromosome inactivation. In X chromosome inactivation, approximately 70% of genes on the short arm and nearly all of the genes on the long arm of the designated chromosome are inactivated. RNA activation is known to RNAs activating gene expression; however its roles in X chromosome inactivation have not been determined.