Protein tyrosine nitration (PTN) is a post-translational modification that occurs under the action of Nitric oxide (NO) which leads to the formation of reactive nitrogen species (RNS). RNS reacts with tyrosine residues in proteins to form nitrotyrosine. PTN has lately been related to neurodegenerative diseases. It is very essential to know the details of its mechanism. PTN is also involved in cellular signaling. The detail of such an event is still not clear. Controlling of cellular signaling is only possible if nitration and denitration is a dynamic, regulated and reversible process. In this review, the biological consequence of PTN, analytical methods required for their detection and their relation with different neurological diseases has been discussed in details
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A 14 year-old previously healthy Hispanic female was noted to have pancytopenia at an emergency center visit where she was evaluated due to 2 weeks of cough, malaise, and low-grade fever. She was prescribed Azithromycin and Methylprednisolone, but never began the steroid.
Jugular versus Mammary Vein Acid-Base Balance, Blood Gases, Hematobiochemical Profiles and Inflammation Biomarkers in Goats with Acute Mastitis
The objectives of this study was to investigate the acid-base balance, blood gases, hematobiochemical profiles and the inflammation biomarkers fibrinogen, serum amyloid A (SAA) and haptoglobin (Hp) in the mammary and jugular veins of goats with mastitis. Blood samples were collected from the jugular and mammary veins from 26 goats with mastitis and from 10 healthy lactating goats. In diseased goats, the affected quarter had a remarkable degree of swelling, hard and sore to touch; the milk was bloody. In the jugular vein of diseased goats, the values of PCO2, PO2, base excess (BE), HCO3 and TCO2 were significantly lower than in the jugular vein of controls.
Chronic anal fissure is a commonest anal condition of world population and our country is not an exception. Conservative management is initially recommended with creams and oral analgesics. When conservative measures fail despite of recommended length of therapy, surgical option is offered to the affecters.