Open Access Journals

All Science and Engineering articles published in our Open Access journals are freely accessible to read, download and share..

Publish Your Research Papers

Annex Publishers is a center for researchers and scientists who work hard to bring a far higher tomorrow for humanity.
  • Annex Publishers

    Annex publishers is an Open Access publication model which allows the publication of articles to the world through this community. We provide you the asset of interaction with the most researchers from the scientific community. Anyone can freely access the articles printed under Annex publishers.
  • Why Open Access?

    Open access provides an unlimited access to journals and publications, with a perfect platform for thousands of researchers to form jointly for the development of science. Open Access assists in accelerating the scientific discovery, encourage innovation, enhance education and refresh the economy to build up the knowledge of the general public.
Submit Manuscript


Recent Articles

Overuse and Misuse of Adjuvant Chemotherapy for Stages I and II Non-Small Cell Lung Cancer Chemotherapy: Empirical Findings from a Privately Insured Population

Among persons with early stage non-small cell lung cancer (NSCLC) resected for cure, appropriate use of adjuvant chemotherapy is an important additional determinant of survival. Oncology quality improvement initiatives focus on reducing overuse, underuse, and misuse.

The Field of Emergence in the Aspects of Communicative Situation

Communicative situation is a basis, which designates potential models of “constructed forms”. It is within the field of emergence models of text, that can be potentially prognosticated in a certain communicative situation, are designated. Every text can be assumed as conceptual system structured on the base of certain communicative situation.

Validation of an Anti-Protective Antigen ELISA for Quantitative IgG Evaluation in B. anthracis Immunized Horses

The potency test for anthrax vaccines has historically involved the challenge of actively or passively immunized laboratory animals with a fully virulent strain of Bacillus anthracis. Lethal challenge studies with the archetypal virulent strains such as B. anthracis Ames strain present considerable difficulties in laboratory management and handling and are too inefficient for the early evaluation of alternative preventative and therapeutic interventions. An ELISA for the evaluation of antibody response to protective antigen (PA) in horses immunized with the Sterne 34F2 strain spore vaccine was developed. The objective of this work was to study the performance of this assay in terms of the guidelines set forth by the International Conference on Harmonics (ICH) and the Center for Biologics Evaluation and Research (CBER) for analytical procedures. We have demonstrated a working range for this assay (73-1581 EU/ml) on the bases of the following parameters: linearity (25 and 1,662 EU/ml, r2 = 0.9988, p < 0.001), accuracy (94.8 - 105.4 %, recovery within the range of 25 and 1,662 EU/ml), precision (≤ 17.6 % CV, repeatability; ≤ 15.7 and ≤ 13.1 % CV, intermediate precision per day and per analyst, respectively), limit of detection (2.25 EU/ml) and limit of quantitation (25 EU/ml). The assay was also demonstrated to be specific for the evaluation of anti-PA IgG antibodies. Based on the assay performance characteristics it was determined that the assay was adequate for use in B. anthracis immunogenicity testing in horses.