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    Annex publishers is an Open Access publication model which allows the publication of articles to the world through this community. We provide you the asset of interaction with the most researchers from the scientific community. Anyone can freely access the articles printed under Annex publishers.
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Recent Articles

Wet Granulation to Overcome Liquisolid Technique Issues of Poor Flowability and Compactibility: A Study to Enhance Glibenclamide Dissolution

The aim of this study is to apply wet granulation on liquisolid powders to overcome issues of poor powder flowability and compressibility especially with using high viscosity liquid vehicles. Different liquisolid formulations were made using three excipients where the effect of each excipient used in the dissolution of the model hydrophobic drug (Glibenclamide) was evaluated. The Glibenclamide tablets were formulated using PEG 400, Synperonic PE/L44 and Cremophor ELP, at a 10 %w/w in liquid vehicle drug concentration. The carrier (Avicel®PH102) was used followed by colloidal silicon dioxide (coating material) that converted the wet mixture into dry powder. Potato starch, 5%w/w, as a disintegrant was mixed with the mixture manually for 10 minutes and was finalized by adding 0.75% of magnesium stearate as a lubricant.

Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection

Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.