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Recent Articles

Detection of a Rheumatic Factor (RF,) Anti- Cyclic Citrullinated Peptides (Anti CCP) Antibodies and C- Reactive Protein (CRP) in Diagnosis and Prognosis of Rheumatoid Arthritis

Introduction: Rheumatoid arthritis ( RA)is an autoimmune and inflammatory disease. It is characterized by arthrosynovitis with resultant joint destruction . So, an early clinical diagnosis along with simple serological tests like anti CCP antibodies, C –reactive protein ( CRP) and Rheumatoid factor (RF) play an important role .An attempt was made to study and compare these parameters in OPD and IPD RA patients in our hospital setup, VMMC and Safdarjung Hospital , New Delhi. Aims and Objectives: To study the role of RF , Anti-CCP antibodies and CRP in early detection and prognosis of Rheu- matoid arthritis. Materials and Methods: A Total of 440 samples were studied from January 2018 to December 2020 (3years). Correlation between Rheumatoid factor(RF) ,anti CCP antibodies and CRP in suspected RA patients from various departments like PMR , Orthopaedics , Medicine, Obstetrics and Gynaecology and Paediatrics was attempted. RF and CRP was performed using latex agglutination test and anti CCP antibody by ELISA. Results and Conclusion: Of 440 samples tested, all the factors were positive in 87 patients . Anti CCP and RF alone was seen in 32 patients. RF and CRP positive in 49 patients, RF alone in 22 patients. In 250 patients all the tests were negative. So, Anti CCP along with RF and CRP showed a better positive predictive value in patients of Rheumatoid arthritis. But positivity of these parameters even in patients who lack sign and symptoms also aids in better diagnosis, treatment and prognosis.

Does Pre-Workout Supplement Consumption Affect Enamel Microhardness?

The aim of this study was to compare in vitro the micro hardness of enamel exposed to the erosive effects of three pre-workout drinks. Forty blocks (4mmx4mm) of bovine enamel were randomly selected and divided among the following pre-workout drinks (n=10): G1: Universal Shock Therapy®, G2: 1.M.R Vortex™, G3: Jack3Dmicro™, G4: Control (distilled water). The enamel microhardness was evaluated before (T1) and after (T2) the in vitro erosive test (5 min/3 times/5 days) using a Vickers digital microduremeter (load 100g/penetration 15s). The data was analyzed using descriptive statistics (mean, ±sd) and for comparison testing, using the Kruskall Wallis test and the t Student test (p≤ 0.05). All groups showed a reduction in micro hardness after the erosive test (p =0.001).1.M.R Vortex™ drink showed a large decrease in micro hardness (%SMH:34,92%). Pre-workout drinks significantly decreased the superficial micro hardness of enamel

Demographic and Socioeconomic Influence on Antenatal Care Utilization Among Pregnant Women in Wa Municipality of The Upper West Region of Ghana

Introduction: It remains unclear if benefits of antenatal care can be attributed to the amount and content of care or to uncontrolled risk factors that might also affect its use. An understanding of the factors influencing antenatal care is still a challenge because the pathways through which the effects are obtained remain elusive. Objective: The study examined the factor influencing antenatal care utilisation in the Wa Municipality. Methodology and Data: The study employed a retrospective cohort design. The probability proportionate to size sampling was used to select the sub-district health catchment facilities, while the systematic random sampling was used to select respondents. Data was collected from 353 women based on the status of Antenatal care utilization. Results: The results suggest that the educational status, maternal knowledge on adequacy of four or more antenatal care, score for general services received, number of tetanus toxoid doses received and anaemia status at Antenatal care registration were significant predictors to adequate antenatal care utilization. Conclusion: The study further found that women who had anaemia at antenatal care registration, General quality of received women received at antenatal care, level of Tetanus doses as well as knowledge on the adequacy of antenatal care were significant factors that influence antenatal care usage among reproductive aged women in the Wa municipality. The implication is that, attention should be drawn by health management authorities to ensure an improvement in the coverage antenatal care in Wa Municipal while health staff are encouraged to enforce to the latter all due protocols in the discharge of their duties at antenatal care utilisation in Ghana

A Diagnostic Dilemma of Pancreatic Adenocarcinoma: The Duct Cut-off Sign

Pancreatic cancer carries one of the worst prognoses in the United States. It is the fourth leading cause of cancer-related death in the United States and second after colorectal cancer in digestive system cancer-related death. Early detection is the key to improving its prognosis. Surgical resection is the only curative treatment, but even after margin-negative resection, the 5-year survival rate is still 30%. The following case presents a fascinating diagnosis of pancreatic cancer. Despite an initial diagnosis of pancreatitis, negative cytology, tumor markers, and imaging suggestive of intraductal papillary mucinous neoplasm (IPMN), this patient underwent surgical resection that later revealed pancreatic adenocarcinoma of the tail. This article highlights certain imaging modalities and characteristics that are essential in the diagnosis of pancreatic adenocarcinoma, in an effort to guide management of similar cases, with hope it leads to better outcomes.