Annex Publishers

This article presents a new model of obstetrical pessary for prevention and treatment of cervical insufficiency and habitual abortion. In 2012 Research Center for Obstetrics, Gynecology and Perinatology (of the Ministry of Health of Russia) received an assignment from the Ministry of Health of Russia to develop a new medical device for correction and treatment of conditions associated with habitual abortion. In accordance with this task, a group of the Center`s researchers and obstetricians developed a new model of obstetrical pessary. In 2013 the Ethics Commission on biological and medical investigations of the Center authorized clinical use of this device.

Tissue cytokine levels (IL-1β, TNF-α and IL-10) have been utilized for screening, diagnosis, prognostication and treatment of tumors. The current study, therefore, purports to measure the levels of common cancer associated cytokines in histopathologically confirmed tissue samples of eyelid tumors.

Over the course of several years, three members of a Bottlenose dolphin (Tursiops truncatus) group showed periodical bouts of pruritus and dermatological lesions. The affected animals were a 25-year-old cow and her 5 and 7-year-old offspring, all housed in a mixed indoor/outdoor facility. The signs were first noted in 2005 and escalated over time until 2012, when a final diagnosis of the problem was attempted. Diagnostic tests included blood analysis and skin biopsies, swab microbiological cultures from the wheals, intradermal tests and response to treatment with corticosteroids. Clinical picture and histopathological findings, as well as response to methylprednisolone, were considered compatible with an allergic dermatitis.

The C28/I2 line of immortalized juvenile human chondrocytes was employed to determine the extent to which recombinant human (rh) interleukin-6 (rhIL-6), the interleukin-6-like cytokine, rh-oncostatin M, and the adipokine, rh-adiponectin, activated extracellularsignal regulated kinase (ERK1/2), p38α mitogen-activated protein kinase (p38α MAPK) and c-Jun-amino-terminal kinase (JNK).